Raquel Kindlovits, Ana Catarina Sousa, João Luís Viana, Jaime Milheiro, Bruno MPM Oliveira, Franklim Marques, Alejandro Santos, Vitor Hugo Teixeira
Nutrients 2025, 17(3), 522
This article, authored by Raquel Kindlovits and colleagues, aimed to evaluate the effects of an exercise intervention in hypoxia (EH) under normobaric conditions, for eight weeks, at an altitude of 3000 m simulated through nitrogen dilution, in combination with a control diet (Control – 60% of energy from carbohydrates, 20% from protein and 20% from lipids) or with a low-carbohydrate, high-fat diet (LCHF – low carbohydrate high fat diet, with 40% of energy from carbohydrates, 20% from protein and 40% from fat) on hematological and lipid profiles, inflammation and blood pressure in individuals over 65 years of age with type 2 diabetes mellitus (T2DM) and coexisting hypertension (HTN).
Both diets prioritized foods with a low glycemic index, as recommended in multiple treatment guidelines for T2DM.
This was the first RCT to examine the responses to exercise in chronic hypoxia with and without a LCHF diet on hematological and lipid profiles, inflammation, and blood pressure in patients with T2DM and HTN.